The key symptoms of Opioid dependence with withdrawal are: Taking opioids in larger amounts or over a longer period than was intended, including running out of a prescription early on most refill cycles., Persistent desire or repeated unsuccessful attempts to cut down or control opioid use, often described as 'every Monday I tell myself I'll stop'., Spending a great deal of time obtaining opioids, using them, or recovering from their effects — sometimes much of the waking day., Strong cravings or urges to use opioids, often triggered by physical pain, emotional distress, drug paraphernalia, or specific people and locations., Recurrent opioid use leading to failure to fulfill obligations at work, school, or home — missed shifts, missed appointments, missed parenting., Continued opioid use despite persistent or recurrent social or interpersonal problems caused or worsened by the substance., Important social, occupational, or recreational activities are given up or reduced because of opioid use..
01Taking opioids in larger amounts or over a longer period than was intended, including running out of a prescription early on most refill cycles.
02Persistent desire or repeated unsuccessful attempts to cut down or control opioid use, often described as 'every Monday I tell myself I'll stop'.
03Spending a great deal of time obtaining opioids, using them, or recovering from their effects — sometimes much of the waking day.
04Strong cravings or urges to use opioids, often triggered by physical pain, emotional distress, drug paraphernalia, or specific people and locations.
05Recurrent opioid use leading to failure to fulfill obligations at work, school, or home — missed shifts, missed appointments, missed parenting.
06Continued opioid use despite persistent or recurrent social or interpersonal problems caused or worsened by the substance.
07Important social, occupational, or recreational activities are given up or reduced because of opioid use.
08Recurrent opioid use in physically hazardous situations such as driving, operating machinery, or caring for children while impaired.
09Continued use despite knowledge of a persistent physical or psychological problem caused or worsened by opioids — often constipation, fatigue, depression, or low testosterone.
10Tolerance — needing markedly increased amounts of opioid to achieve the same effect, or markedly diminished effect from the same amount.
11Withdrawal syndrome when opioid use is reduced or stopped — yawning, lacrimation, rhinorrhea, sweating, dilated pupils, gooseflesh, anxiety, restless legs, abdominal cramps, vomiting, diarrhea — or taking opioids to relieve or avoid these symptoms.
